Warrants

Pre-Funded Warrants

Weighted

Weighted

Average

Average

Exercise 

Exercise 

Warrants

Price

Warrants

Price

Outstanding at January 1, 2019

713,652

$

26.19

—

$

—

Granted

1,837,421

$

2.35

868,443

$

0.001

Expired

(88,010)

$

38.70

—

$

—

Outstanding at December 31, 2019

2,463,063

$

7.96

868,443

$

0.001

Granted

705,688

$

8.90

—

$

—

Exercised

(589,941)

$

2.39

(548,242)

$

0.001

Held in abeyance

(803,300)

$

2.32

—

$

—

Expired

(625,642)

$

24.44

—

$

—

Outstanding at December 31, 2020

1,149,868

$

6.36

320,201

$

0.001